Bromantane – Spray Solution (90mg/mL) PRE-ORDER

$33.99

✓ High quality reference material

✓ Contains 180 sprays per bottle

✓ Approximately 9mg per spray

✓ Estimated 90 days of research supply

Application‎‎‎‎‎‎‎‎ㅤ Dopamine upregulator
CAS 87913-26-6
Molar Mass 306.25 g/mol
Chemical Formula C16H20BrN
IUPAC Name N-(4-bromophenyl)adamantan-2-amine
Synonyms 2-bromophenyl-1-amino adamantane, bromontan, 87913-26-6, Bromantan, N-(2-ADAMANTYL)-N-(4-BROMOPHENYL)AMINE, N-(4-bromophenyl)adamantan-2-amine, UNII-N1ILS53XWK, 2-(4-Bromophenyl)aminoadamantane, N1ILS53XWK, C16H20BrN, Ladasten, PubChem21584, AC1NFLP6, MolPort-012-150-352, ZINC2577057, N-(4-bromophenyl)-2-adamantanamine, AKOS004120981, MCULE-9093089711, AS-54469, N-(2-adamantyl)-N-(p-bromophenyl)-amine, FT-0663607, N-(4-BROMOPHENYL)TRICYCLO[3.3.1.1(3,7)]DECAN-2-AMINE, 138308-72-2, O035, A842407
Storage Store at room temperature, tightly sealed, away from heat, light and moisture. Do not refrigerate.
Solubility Soluble in Chloroform (Slightly), Ethyl Acetate (Slightly), PEG400 (Moderately), Caprylic acid
Organoleptic Profile Clear liquid
Physical Form Liquid, solved in Caprylic acid
Specification 90mg/mL±10% in 18mL, purity 99%+. Chemical analysis available on request.
Terms This material is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.

Notice (10/02/22): Temporarily out of stock, will be back within a week.

Available on backorder

Description

Buy Bromantane Spray | Dopamine upregulating nootropic | Read more:

Background

Bromantane increases dopamine without addiction, tolerance or withdrawal [2][3]. Despite being classified as a psychostimulant, it is distinct from others in its class. Any perceived stimulatory effects are mild, and studies report decreased anxiety among subjects [1]. This has made Bromantane a hugely interesting compound, though it was neglected for many years for unknown reasons.

In Russia it was used under the name “Ladasten” for the treatment of asthenia, which is similar to chronic fatigue syndrome. In a study of over 700 patients, it was concluded that Ladasten was not only safe but even lacked side effects [1]. Western medicine has paid little attention to Bromantane, however Algernon Pharmaceuticals is now investigating it for its antifibrotic, kidney-protective effects. We hope to encourage such research by allowing researchers to buy Bromantane.

Pharmacology

Bromantane’s mechanism is thought to be like that of Amantadine’s: Kir2.1 potassium channel inhibition [4]. Similarity is shared not only in downstream effects, but chemical structure.

High dopamine biasedly enforces synaptogenesis in D1-containing direct medium spiny neurons, and this creates an imbalance with D2-containing indirect medium spiny neurons. Kir2.1 potassium channel inhibition, however, corrects this, therefore improving disorders such as dyskinesia, psychosis and other detriments caused by abnormally high dopamine.

The anti-inflammatory effects of these compounds indirectly inhibit histone deacetylases, and this gives rise to neurotrophins such as BDNF and especially GDNF. As seen in Parkinson’s patients, GDNF injections had benefits lasting up to 3 years after stopping, maybe explaining Bromantane’s dopaminergic effect which lasts for 2 months after discontinuation. Reduced neuroinflammation and increased neurotrophins also functions as a dual protective measure against neurotoxicity in dopamine neurons.

Bromantane’s benefit to athletic ability may be multifaceted: it may draw influence from the central nervous system as described above, but it may also be secondary to testosterone and/ or tissue oxygenation. Like Bemethyl (Metaprot), Bromantane is in a class of compounds called “actoprotectors”, primarily known for their antihypoxic effects. And like Bemethyl, both are antioxidants, which is believed to underlie these effects (albeit Bromantane a stronger antioxidant). This could be how Bromantane improves testosterone, although the marked reduction to cortisol could also play a role. This combined with the increase in GABA is likely what gives Bromantane an anxiolytic effect.

Pharmacokinetics

Bromantane’s is mistakenly publicized as having a 42% oral bioavailability, however its absolute bioavailability is only 27.5% [5]. Additionally its elimination constant is nearly 60 times higher given orally than intravenously, which could be explained by its accumulation and therefore saturation of the liver which excretes it in the form of oxidized metabolites [5]. This means that other routes of administration, such as intranasal or intravenous, could not only multiply its total absorption, but drastically increase its half life which may be necessary for some effects demonstrated in rodent models.

References

[1] Clinical Trials: https://pubmed.ncbi.nlm.nih.gov/21322821/

[2] Upregulation: https://pubmed.ncbi.nlm.nih.gov/11109517/

[3] Lack of withdrawal or addiction: https://pubmed.ncbi.nlm.nih.gov/19491814/

[4] Amantadine’s mechanism of action: https://www.jci.org/articles/view/133398

[5] Book on Bromantane: http://library.lol/main/CD8E44AA817FFB656E936429BF0A8496

Disclaimer

Scientific discussion is purely for educational purposes. This is not medical advice.

Additional information

Weight 0.0850485694 kg
Dimensions 3.175 × 3.556 × 10.795 cm
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